Trials / Recruiting
RecruitingNCT05120518
Post Mortem Tissue Donation of Pediatric Tumor Tissues and Cells
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 150 (estimated)
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
The objective of this study is to utilize all donated pediatric tumor tissues and cells obtained from autopsy to prospectively develop novel patient derived orthotopic xenograft (PDOX) mouse models as well as in vitro cell culture model systems for pediatric cancers, and also provide tissue samples to other researchers and organizations (eg, CBTN, DIPG Registry, COG).
Detailed description
The objective of this study is to utilize all donated pediatric tumor tissues and cells obtained from autopsy to prospectively develop novel patient derived orthotopic xenograft (PDOX) mouse models as well as in vitro cell culture model systems for pediatric cancers, and also provide tissue samples to other researchers and organizations (eg, CBTN, DIPG Registry, COG). This model system will then be subjected to 1) comprehensive histopathological and molecular characterizations during serial in vivo sub-transplantations; 2) cryopreserved for long term preservation of tumorigenicity; and 3) used for future biological studies and preclinical drug testing.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Collection of post mortem tissue donation | Collection of post mortem tissue from pediatric participants with cancer and non-cancer tumor types from whom post mortem tissue donation and autopsy consent is obtained. |
Timeline
- Start date
- 2019-08-14
- Primary completion
- 2029-08-14
- Completion
- 2029-08-14
- First posted
- 2021-11-15
- Last updated
- 2024-11-12
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT05120518. Inclusion in this directory is not an endorsement.