NCT05118711

Sequelae of COVID-19 With Focus on Exercise Capacity and Underlying Mechanisms

COVID-19 Severity, Long-term Consequences for Exercise Capacity and Link to Associated Mechanisms

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 128 (estimated)
• Sponsor: Arno Schmidt-Trucksäss · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Accepted

Summary

The project is designed as a cross-sectional study and aims to examine long-term consequences of coronavirus disease 2019 (COVID-19) for selected bio-behavioural parameters while taking the disease course severity into account.

Conditions

• Patients Post-COVID-19
• Controls

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Cardiorespiratory fitness	Cardiopulmonary exercise testing
DIAGNOSTIC_TEST	Lung function	Body plethysmography
DIAGNOSTIC_TEST	Muscular strength and balance tests	Handgrip strength test, mid-thigh pull test and standing balance test in static tandem stance
DIAGNOSTIC_TEST	Micro- and macrovascular endothelial function and cardiac function	Measurement of flow-mediated dilation, static and dynamic retinal vessel analysis, echocardiography
DIAGNOSTIC_TEST	Blood sampling and analysis	Blood sampling by venepuncture
DIAGNOSTIC_TEST	Physical activity	Physical activity surveillance using accelerometers
DIAGNOSTIC_TEST	Questionnaires	Global physical activity questionnaire (GPAQ), short-form 8 health survey (SF-8), barriers to physical activity, fatigue assessment scale (FAS), modified medical research council dyspnea scale (mMRC), depression, anxiety, and stress scale (DASS21), post-COVID-19 syndrome symptoms
DIAGNOSTIC_TEST	Body composition	Dual-energy x-ray absorptiometry (DXA)

Timeline

• Start date: 2023-01-03
• Primary completion: 2024-03-01
• Completion: 2024-03-01
• First posted: 2021-11-12
• Last updated: 2023-02-10

Locations

1 site across 1 country: Switzerland