NCT05118698

Explore the Effect of Gynostemma Pentaphyllum on Patients With Metabolic Syndrome

An Intervention Study of Gynostemma Pentaphyllum in Patients With Metabolic Syndrome

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: First Affiliated Hospital Xi'an Jiaotong University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Previous research shows that gypenoside could keep blood lipid and blood sugar under control in an effective way. In this study, we intend to explore whether gypenosides have clinical improvement effects on metabolic diseases such as diabetes, hyperlipidemia, and non-alcoholic fatty liver and their cardiovascular protective potential. It is designed to recruit 150 patients with metabolic syndrome diagnosed who meet the criteria for enrollment, and randomly divide them into three groups. Gynostemma powder, with two different saponins content (12% and 8%) from Pingli County, Shaanxi Province, and spinach powder with almost no saponins were used to conduct the intervention on patients. Patients will be followed up regularly at the beginning of each month from the first enrollment until the third month. At each follow-up, data of patient's anthropometric indicators as well as clinical inspection indicators related to metabolism (blood routine, liver function, etc.) will be recorded. In addition, patient's blood, hair, urine, and stool samples will be collected to further explore the mechanism of diseases.

Conditions

• Metabolic Syndrome

Interventions

Type	Name	Description
DRUG	Gynostemma	Patients in the high-dose group and low-dose group will take gynostemma powder with a saponin content of 12% and 8% respectively, 3 times a day for 3 months.
OTHER	Spinach	For the spinach powder group, each patient will take spinach powder with nearly no saponin content, 3 times a day for 3 months.

Timeline

• Start date: 2022-03-01
• Primary completion: 2022-10-30
• Completion: 2023-03-01
• First posted: 2021-11-12
• Last updated: 2022-07-11

Locations

1 site across 1 country: China