NCT05118126

Gut Microbiota in ITP

Diagnostic and Therapeutic Value of Gut Microbiome in Adult Immune Thrombocytopenia

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 240 (estimated)
• Sponsor: Peking University People's Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Prospective, observational study to explore the significance of gut microbiome in the diagnosis of ITP, and to identify the predictive value of baseline gut microbiome for GC resistance/relapse.

Detailed description

A prospective, observational study to (1) collect fecal samples from ITP patients at initial diagnosis (baseline) and after first-line GC treatment, (2) detect the composition of gut microbiome and related metabolites using metagenomic sequencing combined with metabolomics, (3) observe the impact of first-line treatment on gut microbiome, (4) explore the significance of gut microbiome in the diagnosis of ITP, and (5) identify the predictive value of baseline gut microbiome for GC resistance/relapse, thus to provide new ideas for clinical diagnosis and treatment of ITP.

Conditions

• ITP

Timeline

• Start date: 2022-01-01
• Primary completion: 2022-06-01
• Completion: 2022-12-01
• First posted: 2021-11-11
• Last updated: 2022-01-12

Locations

1 site across 1 country: China