NCT05117047

A Long-term Survival Analysis of Different Surgical Method in Early Hepatocellular Carcinoma

Long-term Survival Analysis of Robotic, Laparoscopic and Open Liver Resection for Hepatocellular Carcinoma in BCLC Stage 0-A: A Prospective Cohort Study With Matched Comparison

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 369 (actual)
• Sponsor: Chen Xiaoping · Academic / Other
• Sex: All
• Age: 14 Years – 75 Years
• Healthy volunteers: —

Summary

The investigators established three prospective cohorts of patients with BCLC stage 0-A HCC, based on different surgical approaches (open, laparoscopic and robotic). After 5 years of follow-up, the investigators used propensity score matching (PSM) to reduce selection bias and then compared the long-term oncological outcomes of the three different surgical approaches, which might provide high-level evidence in non-randomized observational studies.

Detailed description

In this study, three prospective cohorts of patients with BCLC stage 0-A HCC, underwent complete liver resection using different surgical approaches (OLR, LLR, and RALR), were established. After adequate periods of follow-up, the long-term oncological outcomes of the three different surgical approaches were compared, providing a higher level of evidence using a non-randomized comparative study based on propensity score matching (PSM) analysis.

Conditions

• Long-term Effects of Cancer Treatment

Interventions

Type	Name	Description
PROCEDURE	liver resection	After adequate periods of follow-up, the long-term oncological outcomes of the three different surgical approaches were compared, providing a higher level of evidence using a non-randomized comparative study based on propensity score matching (PSM) analysis.

Timeline

• Start date: 2015-02-14
• Primary completion: 2017-06-30
• Completion: 2021-06-30
• First posted: 2021-11-11
• Last updated: 2021-11-11

Locations

1 site across 1 country: China