NCT05115643

Brain and Muscle Plasticity During Immobilization

Examining Changes in Muscle Size and Strength, Neuromuscular Function, and Brain Plasticity During Limb Immobilization in Women

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: McGill University · Academic / Other
• Sex: Female
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

Patients in rehabilitation may undergo periods of prolonged limb immobilization in response to injury, surgery, or illness. Due to disuse, the size and strength of muscles controlling the affected limb can decrease significantly, possibly resulting in physical impairment or lower quality of life during the recovery phase. Prior immobilization studies have shown that the rate and degree of decline in muscle strength exceeds that of muscle size, indicating that determinants of muscle strength unrelated to muscle size may further contribute to functional changes during immobilization. The purpose of this study is to describe the changes in muscle strength, muscle size, corticospinal excitability, voluntary activation, M1 cortical thickness, and resting state functional connectivity following a 2-week limb immobilization period in young women.

Conditions

• Muscle Atrophy

Interventions

Type	Name	Description
BEHAVIORAL	Immobilization	Immobilization of left arm using a brace and sling.

Timeline

• Start date: 2021-10-08
• Primary completion: 2022-04-21
• Completion: 2022-04-21
• First posted: 2021-11-10
• Last updated: 2022-05-19

Locations

1 site across 1 country: Canada