NCT05115136

Using Doxepin for Urticaria

The Use of Doxepin for Urticaria in the Emergency Department

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 160 (estimated)
• Sponsor: State University of New York - Upstate Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Isolated urticaria in the emergency department is widely treated by physicians with histamine blocking agents such as diphenhydramine, cetirizine, and cimetidine. Doxepin is a tricyclic antidepressant that has been shown to have much higher concentrations of histamine blocking activity and therefore may be useful in treating urticaria. The purpose of this study is to compare the effectiveness of using doxepin verses a traditional medication, diphenhydramine (Benadryl), in the treatment of isolated urticaria in the emergency department.

Conditions

• Urticaria

Interventions

Type	Name	Description
DRUG	Doxepin	25mg dose of Doxepin will be administered one time, by mouth
DRUG	Diphenhydramine	50 mg dose of Diphenhydramine will be administered one time, by mouth

Timeline

• Start date: 2022-05-23
• Primary completion: 2023-01-31
• Completion: 2023-07-01
• First posted: 2021-11-10
• Last updated: 2022-05-18

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study