NCT05112731

Role of Glycation and Inflammation in Acute Ischemic Heart Disease

Action of Glycation and Inflammation in Operative Ischemic Heart Disease

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 16 (actual)
• Sponsor: GEK Srl · Industry
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This study requires the consecutive enrollment of 60 patients following the first event of acute myocardial infarction, evaluating B-Cell Activating Factor (BAFF) and methylglyoxal (MGO) levels in the acute setting (pre-reperfusion) and 3 months after reperfusion.

Detailed description

This study requires the consecutive enrollment of 60 patients at admission for first acute myocardial infarction. At enrollment, before reperfusion, a blood sample is obtained to measure B-Cell Activating Factor (BAFF) and methylglyoxal (MGO) levels in the acute setting. This measure is then repeated at follow-up visit 3 months after reperfusion. The aim of the study is to identify specific subsets of patients and evaluate biomarkers variations.

Conditions

• Myocardial Infarction
• Glycation End Products, Advanced
• Inflammation
• Heart Injuries
• Heart Inflammation

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	BAFF and MGO	measurement of BAFF and MGO levels before reperfusion and after 3 months

Timeline

• Start date: 2022-02-01
• Primary completion: 2023-12-31
• Completion: 2023-12-31
• First posted: 2021-11-09
• Last updated: 2024-02-16

Locations

1 site across 1 country: Italy