NCT05111379

Acute Local Metabolomic Alterations in Blood and Muscle Tissue in Intermittent Claudication

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: University of Tartu · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The most common clinical presentation of lower extremity arterial disease is intermittent claudication. Current understanding of the pathophysiology of intermittent claudication, as well as its treatment options are limited. The progression of the disease may lead to lower limb amputation, which is devastating for patients' quality of life and is a huge socio-economic burden to society. Current study allows to determine the acute local metabolomic alterations in the ischaemic limb of the patient with intermittent claudication, and investigate the associations between the metabolomic alterations and the patient's maximal walking distance. This provides potentially valuable insight into the pathophysiology of this disease, and helps lay the groundwork for identifying potential novel targets for instituting more effective therapies for this high-risk population.

Conditions

• Peripheral Arterial Occlusive Disease Fontaine Stage IIa

Timeline

• Start date: 2022-01-28
• Primary completion: 2023-08-01
• Completion: 2025-08-01
• First posted: 2021-11-08
• Last updated: 2022-05-25

Locations

1 site across 1 country: Estonia