NCT05111223

Testing the Contribution of Orbitofrontal Cortex Networks to Decision-making

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Northwestern University · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This research study examines the contribution of orbitofrontal cortex (OFC) networks to decision-making.

Detailed description

This study will combine functional magnetic resonance imaging (fMRI), non-invasive transcranial magnetic stimulation (TMS), olfactory stimuli, and a devaluation task to define the specific contributions of orbitofrontal cortex (OFC) networks in outcome-guided behavior. We will use network-targeted TMS to modulate activity within anterior OFC and posterior OFC networks, examining if they have different contributions to decision-making. This is a randomized, between-subjects design.

Conditions

• Healthy

Interventions

Type	Name	Description
DEVICE	Real transcranial magnetic stimulation (TMS) before conditioning	Real TMS will be applied using the MagVenture MagPro X100 stimulator with the active side of the Cool-B65 A/P coil before the conditioning phase of the task.
DEVICE	Real transcranial magnetic stimulation (TMS) before devaluation test	Real TMS will be applied using the MagVenture MagPro X100 stimulator with the active side of the Cool-B65 A/P coil before the devaluation test phase of the task.
DEVICE	Sham transcranial magnetic stimulation (TMS)	Sham TMS will be applied using the MagVenture MagPro X100 stimulator with the placebo side of the Cool-B65 A/P coil.

Timeline

• Start date: 2022-07-12
• Primary completion: 2026-08-31
• Completion: 2026-08-31
• First posted: 2021-11-08
• Last updated: 2024-08-19

Locations

1 site across 1 country: United States