Trials / Unknown
UnknownNCT05107843
Integrated Clinical-radiological Analysis of Hypoxia Markers in Pediatric Osteosarcomas
Integrated Clinical-radiological Analysis of Hypoxia Markers in Pediatric Osteosarcomas - Single-center Pilot Study of 32 Patients
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 30 (estimated)
- Sponsor
- University Hospital, Strasbourg, France · Academic / Other
- Sex
- All
- Age
- 1 Year – 20 Years
- Healthy volunteers
- —
Summary
The aim of this pilot study is therefore to retrospectively measure the volume and percentage of necrosis on diagnostic MRI in T1 sequence and in parallel to study the expression of immunohistochemical markers of hypoxia (HIF-1α, CAIX , HIF-2α, pS6, phosphomTor, CD163 and CD68) on diagnostic biopsies of high-grade osteosarcomas from 2007 to 2018 in the Strasbourg center, focusing on the pediatric population. The investigators will systematically carry out a correlation analysis between these different parameters and with the clinical data of these same patients (response to chemotherapy, presence of metastases or not and overall and recurrence-free survival). This will eventually make it possible to highlight new prognostic markers at diagnosis.
Conditions
Timeline
- Start date
- 2020-02-01
- Primary completion
- 2021-12-31
- Completion
- 2021-12-31
- First posted
- 2021-11-04
- Last updated
- 2021-11-04
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT05107843. Inclusion in this directory is not an endorsement.