NCT05106075

Pilot Study to Validate ex Vivo Expression of Specific Biomarkers of Human Resolutive Macrophages

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Centre Hospitalier Universitaire de Besancon · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Human resolutive macrophages are essential immune cells in the resolution of inflammation. This particular type of macrophages remains poorly known and currently there are no biomarkers to identify them in vivo. Within UMR1098-RIGHT, specific biomarkers (secreted molecules and membrane receptors) of human resolutive macrophages (healthy volunteers) have been identified in vitro, but their existence in vivo remains an outstanding issue. An exploratory study (lack of data from the literature) will validate the ex vivo expression of these markers in samples of patients whose inflammation is not, or little, supported by the available therapies (NSAIDs, biotherapies, corticosteroids).

Conditions

• Inflammation

Interventions

Type	Name	Description
PROCEDURE	blood sample or joint fluid or gingival exudate	blood sample collected by peripheral blood mobilization joint fluid collected by punction gingival exudate collected with paper strips

Timeline

• Start date: 2021-07-07
• Primary completion: 2024-01-07
• Completion: 2024-01-07
• First posted: 2021-11-03
• Last updated: 2021-11-03

Locations

2 sites across 1 country: France