NCT05105438

Alternate Day vs. Daily Iron Supplementation in Iron Depleted Women

Comparing Oral Iron Supplementation Using Alternate-day Dosing to the Standard of Care Consecutive-day Dosing in Iron-depleted Women With or Without Mild Anemia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (actual)
• Sponsor: Swiss Federal Institute of Technology · Academic / Other
• Sex: Female
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Iron deficiency (ID) with or without anemia is a major public health problem worldwide, especially in women of reproductive age. Iron supplementation can be an effective strategy to prevent and treat ID and iron deficiency anemia (IDA). Recent studies suggests that giving oral iron every other day would be an optimized dosing regimen with maximized absorption and a lower incidence of gastrointestinal side effects compared to consecutive day dosing. Long-term trials in which participants and investigators are blinded to the dosing interval with iron status and gastrointestinal side effects as study outcomes are needed.

Conditions

• Iron-deficiency
• Iron Deficiency Anemia

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Consecutive Day Dosing	100 mg iron as FeSO4 daily for 3 months, followed by matched placebo daily for 3 months.
DIETARY_SUPPLEMENT	Alternate Day Dosing	100 mg iron as FeSO4 and matched placebo on alternating days for 6 months.

Timeline

• Start date: 2021-12-16
• Primary completion: 2022-08-10
• Completion: 2022-12-08
• First posted: 2021-11-03
• Last updated: 2024-01-24

Locations

1 site across 1 country: Switzerland