Trials / Completed
CompletedNCT05104294
Correlation Between Optical Coherence Tomography Angiography and Photopic Negative Response in Patients With Glaucoma
Correlation Between Optical Coherence Tomography Angiography and Photopic Negative Response in Patients With Primary Open Angle Glaucoma
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 76 (actual)
- Sponsor
- Benha University · Academic / Other
- Sex
- All
- Age
- 35 Years – 55 Years
- Healthy volunteers
- Accepted
Summary
Open angle glaucoma (OAG) is considered a common cause of irreversible vision loss worldwide. It is an optic neuropathy associated with progressive loss and degeneration of the retinal ganglion cell layer (RGC) and its axons (retinal nerve fiber layer; RNFL), which lead to neuroretinal rim excavation and corresponding visual field defects.
Detailed description
Open angle glaucoma (OAG) is considered a common cause of irreversible vision loss worldwide. It is an optic neuropathy associated with progressive loss and degeneration of the retinal ganglion cell layer (RGC) and its axons (retinal nerve fiber layer; RNFL), which lead to neuroretinal rim excavation and corresponding visual field defects. OCT Angiography (OCTA) is a promising tool for diagnosing and monitoring glaucomatous patients. It can evaluate glaucomatous damage and assess the ganglion cells' health by measuring blood flow within the optic nerve and the retina Correlation between vascular , structural and functional changes of the peripapillary retinal nerve fiber (RNFL) and macular/ganglion cell complex (GCC) can lead to early detection of glaucomatous changes.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Optical Coherence Tomography- Angiography | Peripapillary retinal nerve fiber layer thickness, ganglion cell complex, superficial and deep capillary plexus vessel density were measured. |
| DIAGNOSTIC_TEST | Photopic negative response | Both the implicit time and amplitude of PhNR were recorded. |
Timeline
- Start date
- 2020-02-02
- Primary completion
- 2020-07-14
- Completion
- 2020-08-15
- First posted
- 2021-11-02
- Last updated
- 2021-11-02
Locations
1 site across 1 country: Egypt
Source: ClinicalTrials.gov record NCT05104294. Inclusion in this directory is not an endorsement.