NCT05102734

Physiologic Effect of Topical Nitroglycerin on Microcirculation Capacity in Patients With Circulatory Shock.

Trial of a Topical Nitroglycerin Challenge to Detect Reversible Microcirculatory Dysfunction in Patients With Circulatory Shock.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 44 (actual)
• Sponsor: University of Pennsylvania · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This is an open-label, single center, trial that will enroll up to 25 participants with circulatory shock after cardiac surgery. Participants will be administered a topical sublingual nitroglycerin solution and assessed for changes microcirculatory blood flow using incident dark field microscopy.

Conditions

• Circulatory Shock
• Cardiovascular Shock

Interventions

Type	Name	Description
DRUG	Nitroglycerin Topical Product	Topical nitroglycerin solution

Timeline

• Start date: 2021-09-01
• Primary completion: 2022-02-01
• Completion: 2022-03-01
• First posted: 2021-11-01
• Last updated: 2024-04-01
• Results posted: 2024-04-01

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study