Trials / Completed
CompletedNCT05102045
The Effects of Repetitive Transcranial Magnetic Stimulation in Patients With Alzheimer's Disease
The Effects of Repetitive Transcranial Magnetic Stimulation and Aerobic Exercise on Cognition, Balance and Functional Brain Networks in Patients With Alzheimer's Disease
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 27 (actual)
- Sponsor
- Istanbul Medipol University Hospital · Academic / Other
- Sex
- All
- Age
- 60 Years
- Healthy volunteers
- Not accepted
Summary
Objectives: The purpose of this study was to investigate the effects of high-frequency repetitive Transcranial Magnetic Stimulation (rTMS) in Alzheimer's Disease (AD). Methods: Twenty-seven AD patients aged ≥60 years were included in the study and divided into 3 groups (rTMS, Aerobic Exercise (AE) and control). All groups received pharmacological treatment. rTMS group (n=10) received 20 Hz rTMS treatment on bilateral dorsolateral prefrontal cortex, 5 days a week over 2 weeks, and AE group (n=10) received the moderate-intensity aerobic exercise for 50 min sessions, 5 days a week over 2 weeks. Control group (n=10) was only treated pharmacologically. Neuropsychiatric and behavioral status, cognition, balance, functional mobility, and quality of life, and functional brain changes were evaluated before and after the treatment.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | Repetitive Transcranial Magnetic Stimulation | TMS is a non-invasive application that induces changes in neuronal polarization and activity by causing the induction of weak electric currents in a rapidly changing magnetic field. Repetitive TMS (rTMS) refers to the application of regular TMS pulses at fixed intervals. |
| OTHER | Aerobic Exercise | Brisk exercise that promotes the circulation of oxygen through the blood and is associated with an increased rate of breathing. |
| DRUG | Acetylcholinesterase Inhibitors | Donepezil, Rivastigmine, Galantamine were given in combination for Alzheimer's disease. |
| DRUG | Memantine | Memantine were given for Alzheimer's disease. . |
Timeline
- Start date
- 2016-09-01
- Primary completion
- 2017-05-01
- Completion
- 2017-06-01
- First posted
- 2021-11-01
- Last updated
- 2021-11-01
Locations
1 site across 1 country: Turkey (Türkiye)
Source: ClinicalTrials.gov record NCT05102045. Inclusion in this directory is not an endorsement.