Trials / Recruiting
RecruitingNCT05101382
A Retrospective Protocol Empowering Precision Research in Colorectal Cancer (ALFAOMEGA-RETRÒ)
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 500 (estimated)
- Sponsor
- IFOM ETS - The AIRC Institute of Molecular Oncology · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
ALFAOMEGA-RETRÒ will be exploited to retrospectively collect clinical and imaging data and archival samples to be used for validation and correlative studies on markers discovered by cutting-edge translational projects within the AIRC5x1000 program "Insights into the evolving heterogeneity of colorectal cancer (CRC): from mechanism to therapies" (an ongoing multi-institutional research program).
Detailed description
ALFAOMEGA-RETRÒ, the retrospective "mirror" protocol of ALFAOMEGA (protocol n. IFOM-CPO003/2018/PO002), has been designed to build a retrospective collection of clinically annotated data and biological samples retrieved from colorectal cancer patients (CRC). The repository will feed experimental precision research aimed at i) defining a new taxonomy of CRC based on evolutionary patterns (retrospectively assessed on patient's samples), ii) developing and evaluating innovative biomarker-specific therapeutic strategies derived from or together with ALFAOMEGA. The following data and biological samples will be collected: * Clinical Data (Demographics, Medical History, Cancer Diagnosis \& History, Treatment Assessment,). * Imaging Data (CT-Scans, MRI, PET...). * Formalin-Fixed Paraffin-Embedded (FFPE) tissue (either from surgical resections or diagnostic biopsies). * Frozen biological samples (blood, plasma, PBMC, stools, buccal swabs, urines, etc.).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Observation | Retrospective Observation of standard clinical practice |
Timeline
- Start date
- 2020-10-28
- Primary completion
- 2026-06-01
- Completion
- 2026-12-01
- First posted
- 2021-11-01
- Last updated
- 2025-08-24
Locations
13 sites across 2 countries: Italy, Spain
Source: ClinicalTrials.gov record NCT05101382. Inclusion in this directory is not an endorsement.