NCT05100264

Effect of Acidic Vaginal pH on the Efficacy of Dinoprostone for Labor Induction

Effect of Acidic Vaginal pH on the Efficacy of Dinoprostone (PGE2) Vaginal Tablet for Labor Induction in Full Term Pregnant Women: A Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 230 (actual)
• Sponsor: Alexandra Hospital, Athens, Greece · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Acidification of vaginal pH has been proposed as a potential factor that could help increase the efficacy of vaginal prostaglandins in labor induction. The aim of the present randomized controlled trial is to evaluate the impact of an acidic vaginal pH on the progress of labor induction with dinoprostone (Prostaglandin E2 - PGE2) vaginal tablet.

Conditions

• Labor, Induced
• Induced; Birth

Interventions

Type	Name	Description
OTHER	Vaginal washing with 5% acetic acid	Induction of labor (vaginal tablet dinoprostone and vaginal washing with 5% acetic acid)
OTHER	Vaginal washing with 0.9% NS	Induction of labor (vaginal tablet dinoprostone and vaginal washing 0.9% NS)

Timeline

• Start date: 2021-10-29
• Primary completion: 2022-12-29
• Completion: 2022-12-30
• First posted: 2021-10-29
• Last updated: 2024-02-20

Locations

1 site across 1 country: Greece