NCT05098093

Bioavailabity of the Major Metabolites of a Botanical Extract, in Healthy Adults

Bioavailabity of the Major Metabolites of a Botanical Extract, in Healthy Adults : a Randomized, Cross-over, Open-label, Clinical Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 17 (actual)
• Sponsor: Activ'inside · Industry
• Sex: Male
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

Scientific research on the beneficial effects of botanical extracts has led to a better understanding of the role of its bioactive compounds, but the bioavailability in human remains largely unknown. Indeed, the most of publications investigated the bioavailability of metabolites of spices in in vitro cells model or animal experiments but few clinical studies have been conducted. Therefore, the aim of this study is to characterize and quantify in blood, the main metabolite compounds of a botanical extract, following its administration by different routes (oral or sublingual) and with different preparations (extract or powder), in quantity equivalent to those having demonstrated biological properties.

Conditions

• Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	SBE	Hard-shell capsule
DIETARY_SUPPLEMENT	DBE	Hard-shell capsule
DIETARY_SUPPLEMENT	BP	Hard-shell capsule

Timeline

• Start date: 2021-11-23
• Primary completion: 2022-03-21
• Completion: 2022-03-21
• First posted: 2021-10-28
• Last updated: 2023-04-13

Locations

1 site across 1 country: France