NCT05097846

Differences in the Eradication of Helicobacter Pylori by Different Therapies

Comparison of Vonoprazan Fumarate-based Triple Therapy Versus Proton Pump Inhibitor and Bismuth Based Quadruple Therapy in the Eradication of Helicobacter Pylori: a Single-center Prospective Open-label Controlled Study

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: wang xiaoyan · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

To compare the performance of four treatment regimens for radical treatment of Helicobacter pylori, evaluating the efficacy, safety, patient compliance, and socioeconomic evaluation of the four regimens. The four treatment regimens included (1) Vonoprazan Fumarate + amoxicillin + doxycycline, (2) Vonoprazan Fumarate + furazolidone + doxycycline, (3) esomeprazole + colloidal bismuth tartrate + amoxicillin + doxycycline, and (4) esomeprazole + colloidal bismuth tartrate + furazolidone + doxycycline.

Detailed description

A single-center, prospective, open-label, parallel control design was conducted to enroll 100 patients with confirmed Helicobacter pylori infection. Patients were randomly divided into four groups, respectively accept four treatment regimens including (1) Vonoprazan Fumarate + amoxicillin + doxycycline, (2) Vonoprazan Fumarate + furazolidone + doxycycline, (3) esomeprazole + colloidal bismuth tartrate + amoxicillin + doxycycline, and (4) esomeprazole + colloidal bismuth tartrate + furazolidone + doxycycline. The effectiveness, safety and compliance of the four regimens were compared, and the cost-benefit analysis of the different regimens was conducted. The purpose of this study was to explore the most appropriate treatment plan for radical treatment of Helicobacter pylori .

Conditions

• Helicobacter Pylori Infection

Interventions

Type	Name	Description
DRUG	Group1 Vonoprazan Fumarate + amoxicillin + doxycycline	Vonoprazan Fumarate + amoxicillin + doxycycline
DRUG	Group2 Vonoprazan Fumarate + furazolidone + doxycycline	Vonoprazan Fumarate + furazolidone + doxycycline
DRUG	Group3 esomeprazole + colloidal bismuth tartrate + amoxicillin + doxycycline	esomeprazole + colloidal bismuth tartrate + amoxicillin + doxycycline
DRUG	Group4 esomeprazole + colloidal bismuth tartrate + furazolidone + doxycycline	esomeprazole + colloidal bismuth tartrate + furazolidone + doxycycline

Timeline

• Start date: 2021-06-17
• Primary completion: 2022-06-17
• Completion: 2022-10-17
• First posted: 2021-10-28
• Last updated: 2022-02-18

Locations

1 site across 1 country: China