NCT05095896

The Serum Lipid Profiles in ITP: a Retrospective Study

The Serum Lipid Profiles in Immune Thrombocytopenia: a Retrospective Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 457 (actual)
• Sponsor: Ming Hou · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The project was retrospectively undertaking by Qilu Hospital of Shandong University in China. In order to investigate the correlations between platelet indices, serum lipids and bleeding symptoms in ITP.

Detailed description

Background: Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease characterized by increased platelet destruction and impaired thrombopoiesis. Platelet indices changes depending on the morphology and volume of platelets. Serum lipids have been found to affect platelet formation and activity in certain diseases, thus induce the corresponding variation of platelet indices. Objectives: To investigate the correlations between platelet indices, serum lipids and bleeding symptoms in ITP. Methods: The clinical data from 457 ITP patients were retrospectively collected and analyzed, including platelet indices, serum lipids, hemorrhage and therapeutic regimen.

Conditions

• Immune Thrombocytopenia

Interventions

Type	Name	Description
OTHER	ITP patients	ITP patients were enrolled in this study based on Chinese consensus of ITP.12 Patients were excluded as (1) receiving platelet transfusion within 7 days or ITP-related medication within 3 months (2) treated with lipid-lowing agents, including statins, fibrates, niacin, bile sequestrant resins, ezetimibe and so on.

Timeline

• Start date: 2018-01-01
• Primary completion: 2020-12-01
• Completion: 2020-12-01
• First posted: 2021-10-27
• Last updated: 2021-10-27

Locations

1 site across 1 country: China