NCT05093478

The Prevalence of Local Immunoglobulin E (IgE) Elevation and Its Effect on Intranasal Capsaicin Therapy in the Non-allergic Rhinitis Population

The Prevalence of Local IgE Elevation and Its Effect on Intranasal Capsaicin Therapy in the Non-allergic Rhinitis Population

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: The University of Texas Health Science Center, Houston · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study to determine the therapeutic response of non-allergic rhinitis patients that have been subtyped as non-allergic rhinitis with local IgE elevation or non-allergic rhinopathy to intranasal capsaicin based on visual analog scale and optical rhinometry, to determine the prevalence of non-allergic rhinitis with local IgE elevation in this study's cohort of patients with non-allergic rhinitis identified by rhinitis history and negative skin testing for allergic rhinitis, and to determine the change, if any, in intranasal IgE levels after capsaicin treatment.

Conditions

• Non-allergic Rhinitis

Interventions

Type	Name	Description
DRUG	Intranasal capsaicin	Intranasal capsaicin, 5 applications each delivering 2 micrograms in each nostril, separated by 1 hour.
DRUG	topical lidocaine	The nose will be pre-treated with topical lidocaine 15 minutes before each application

Timeline

• Start date: 2019-09-10
• Primary completion: 2023-11-30
• Completion: 2023-11-30
• First posted: 2021-10-26
• Last updated: 2024-12-20
• Results posted: 2024-12-20

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study