NCT05093023

ABCB1 SNPs as Predictors of PIPN

ABCB1 Single Nucleotide Polymorphism Genotypes as Predictors of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 92 (actual)
• Sponsor: Ain Shams University · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study aim is to determine the allele frequencies of 1236 G\>A and 3435 G\>A in ABCB1 and study their association with the incidence and severity of paclitaxel-induced peripheral neuropathy while adjusting for other baseline covariates in Egyptian patients. Additionally, the study aimed at fitting and validating logistic regression models with the aforementioned SNPs evaluated in additive, dominant, overdominant, and recessive genetic models and performing diagnostics for the best model in terms of internal validity.

Conditions

• Paclitaxel Adverse Reaction
• Neuropathy;Peripheral
• Breast Cancer

Interventions

Type	Name	Description
GENETIC	Real-Time PCR	Genomic DNA was extracted from 2 ml of venous blood. ABCB1 1236 G\>A and 3435 G\>A were genotyped using predesigned TaqMan SNP genotyping assays on a stepOne PCR instrument in accordance with the manufacturer's protocol.

Timeline

• Start date: 2018-03-01
• Primary completion: 2020-01-01
• Completion: 2020-01-31
• First posted: 2021-10-26
• Last updated: 2021-10-26

Locations

1 site across 1 country: Egypt