Trials / Unknown
UnknownNCT05089110
Expression of Toll-like Receptors 3 , 7 and 9 in Peripheral Blood Mononuclear Cells of COVID-19 Patients
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 100 (estimated)
- Sponsor
- Assiut University · Academic / Other
- Sex
- All
- Age
- 18 Years – 100 Years
- Healthy volunteers
- —
Summary
The aim of the study is to assess the expression of TLR 3, 7, and 9 in the population of peripheral blood mononuclear cells (PBMC) and in B lymphocytes (CD19+), T lymphocytes (CD4+ and CD8+) using flow cytometry in relation to the clinical parameters and outcome of COVID 19 patients .
Detailed description
Abnormal stimulation of innate immunity may have a great influence on the immunopathogenesis of COVID 19 disease .The involvement of innate immunity receptors-toll-like receptors (TLR)-in the pathogenesis of COVID 19 is not adequately studied. The activation of these receptors by specific ligands is thought to initiate autoimmune processes\[1\]. TLR stimulation leads to increased expression of proinflammatory cytokines (IL-6, IFN
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | blood sample | 5 cm blood sample from COVID-19 patients |
Timeline
- Start date
- 2021-11-01
- Primary completion
- 2024-11-01
- Completion
- 2024-11-01
- First posted
- 2021-10-22
- Last updated
- 2021-10-26
Source: ClinicalTrials.gov record NCT05089110. Inclusion in this directory is not an endorsement.