NCT05087693

Salbutamol Use in Ozone Air Pollution by People With Asthma and/or Exercise Induced Bronchoconstriction (EIB)

Examining the Effect of Salbutamol Use in Asthma and/or Exercise Induced Bronchoconstriction Whilst Exercising in Ozone Air Pollution

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: University of British Columbia · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Salbutamol use is increased in areas with high levels of ozone pollution and the potential consequences of this are not well known. The purpose of this study is to examine the effect of salbutamol on lung function and inflammation in people with asthma and/or EIB exercising in ozone air pollution. To examine this, we are planning a randomized cross over trial where people with asthma and/or EIB complete sub maximal exercise in four conditions on four separate days. The four condition are: ozone + salbutamol, filtered air + salbutamol, ozone + placebo medication, and filtered air + placebo medication.

Conditions

• Asthma and/or Exercise Induced Bronchoconstriction
• Ozone Air Pollution

Interventions

Type	Name	Description
DRUG	Salbutamol	Inhaling 200ug of salbutamol
DRUG	Placebo medication	Inhaling placebo medication
OTHER	Ozone	Breathing 170ppb ozone
OTHER	Filtered Air	Breathing filtered air
OTHER	Exercise	Cycling at 60% of VO2max on a cycle ergometer

Timeline

• Start date: 2021-11-01
• Primary completion: 2023-08-31
• Completion: 2023-08-31
• First posted: 2021-10-21
• Last updated: 2025-03-14
• Results posted: 2025-03-14

Locations

1 site across 1 country: Canada