NCT05082402

Imaging of Retinochoroidal Vasculature in Patients Being Assessed for Cardiovascular Disease

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Northwestern University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

This study aims to determine whether changes in retinal vasculature seen on SS-OCTA can be correlated to degree of cardiovascular disease as measured by carotid duplex ultrasonography.

Detailed description

The study's primary objective is to determine whether measures taken from SS-OCTA, color fundus photography, and retinal exams can correlate with and predict the presence/degree of carotid occlusive disease as determined by carotid duplex ultrasonography by examining the following parameters: retinal vessel caliber, retinal vessel density, retinal vessel perfusion, retinal vessel tortuosity, presence of Hollenhorst or other plaques, and/or areas of ischemia.

Conditions

• Cardiovascular Diseases
• Retina; Change

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Swept Source Optical Coherence Tomography Angiography	The PLEX Elite 9000 is an FDA cleared research device for use in ocular imaging obtained by Northwestern University by way of a purchase agreement with the manufacturer, Carl Zeiss Meditec, Inc. It is currently unavailable outside of participation in the ARI Network, a cloudbased storage and image processing platform using deidentified information shared between academic institutions. The ARI Network is managed by a group of physicians and scientists from around the world that are working to better understand eye diseases.

Timeline

• Start date: 2021-08-17
• Primary completion: 2024-12-31
• Completion: 2024-12-31
• First posted: 2021-10-19
• Last updated: 2024-03-22

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study