Trials / Completed
CompletedNCT05082207
Ischemic Preconditioning and Thiol-disulfide Balance
Effect of Ischemic Preconditioning on Dynamic Thiol-disulfide Balance, Randomized Controlled Trial
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 60 (actual)
- Sponsor
- Konya Meram State Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years – 90 Years
- Healthy volunteers
- Accepted
Summary
Various strategies have been proposed to prevent or mitigate the effects of ischemia-reperfusion injury following the use of tourniquets in orthopedic surgery cases. One of them is applying "remote ischemic preconditioning." This randomized controlled trial is planned to evaluate the effectiveness of remote ischemic preconditioning in preventing tourniquet-induced ischemia-reperfusion injury in total knee arthroscopy with dynamic thiol-disulfide homeostasis.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Remote Ischemic Preconditioning | Three cycles of 5-min upper limb ischemia and 5-min reperfusion using a blood-pressure cuff inflated to a pressure of systolic blood pressure plus 50 mm Hg. |
| OTHER | sham group | a deflated cuff placed on the upper arm for 30 min |
Timeline
- Start date
- 2021-10-16
- Primary completion
- 2022-04-17
- Completion
- 2022-05-15
- First posted
- 2021-10-18
- Last updated
- 2022-08-17
Locations
1 site across 1 country: Turkey (Türkiye)
Source: ClinicalTrials.gov record NCT05082207. Inclusion in this directory is not an endorsement.