NCT05080816

Effects of Parenteral and Enteral Nutrition on Skeletal Muscle Genomics

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 39 (actual)
• Sponsor: Göteborg University · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The study investigates effects related to muscle protein metabolism at provision of Parenteral or enteral nutrition

Detailed description

Randomized study investigation alterations in muscle protein metabolism at provision of parenteral or enteral (oral drink) nutrition. The study uses a genomic/transcriptomic/proteomic approach to evaluate factors related to activation of skeletal muscle protein synthesis and protein degradation. Patients scheduled for major gastrointestinal surgery are included. Muscle specimens are collected during surgery.

Conditions

• Muscle Loss

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Parenteral nutrition (PN)	Overnight infusion of parenteral nutrition. Supplied as all-in-one-bag format. Infusion rate of 0.2 g N/kg/day.
DIETARY_SUPPLEMENT	Enteral nutrition	Oral nutrition drink. 2 \* 200 ml on the night before operation. 1\* 200 ml on the morning of operation day.
OTHER	Control	Overnight infusion of crystalloid fluid (Ringer acetate) infused at the same rate (ml/kg) as intervention PN

Timeline

• Start date: 2017-02-01
• Primary completion: 2018-10-18
• Completion: 2018-10-18
• First posted: 2021-10-18
• Last updated: 2021-10-18

Locations

1 site across 1 country: Sweden