NCT05077618

Nalysis of the Periodontal Microbiota in Elderly Subjects With and Without Alzheimer's Disease: a Case Control Study

Oral Bacterial and Viral Mapping by Dental Plaque in Elderly Patients With and Without Alzheimer's Disease(ORal MICrobiology in Alzheimer's Patients)

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 94 (estimated)
• Sponsor: Centre Hospitalier Universitaire de Nice · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Accepted

Summary

The neurological disorders that accompany aging represent a major public health problem. The management of these diseases is a major medical and social priority. This project is based on the assumption that the oral cavity represents a privileged observation space to address these issues. The mouth is a site of easy access for painless sampling; there is therefore a major interest in identifying early oral infectious markers of the development or evolution of senile dementia. In addition to the interest of an early oral diagnosis, the mapping of the oral microbial flora in the demented elderly would allow a better understanding, prevention or even control of the evolution of neurodegenerative diseases. The final objective of our approach is to characterize the oral pathogens, or more probably the group of oral pathogens, which are significantly associated with Alzheimer's disease.

Conditions

• Periodontitis
• Alzheimer Disease

Interventions

Type	Name	Description
OTHER	sampling of dental plaque and blood sample during the treatment	sampling of dental plaque and blood sample analysed on day 1

Timeline

• Start date: 2023-01-30
• Primary completion: 2023-01-30
• Completion: 2025-07-31
• First posted: 2021-10-14
• Last updated: 2025-03-20

Locations

1 site across 1 country: France