NCT05077007

Evaluation of Renal Damage After PCNL and ESWL Using Novel RNA Based Biomarkers

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 75 (estimated)
• Sponsor: Ain Shams University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The study evaluate the damage effect of ESWL and PCNL on kidney tissue by measuring non-coding lnc-RNA profile in urine before and after ESWL and PCNL procedures

Detailed description

The study evaluate the damage effect of ESWL and PCNL on kidney tissue by measuring non-coding lnc-RNA profile in urine before and after ESWL and PCNL procedures and assess their usefulness as diagnostic biomarkers for AKI and the relationship between the selected RNA based biomarker panel and clinicopathological changes of patients.

Conditions

• Acute Kidney Injury
• Renal Calculi
• Percutaneous Nephrolithotomy
• Extracorporeal Shockwave Lithotripsy

Interventions

Type	Name	Description
PROCEDURE	Percutaneous nephrolithotomy	Endoscopic stone Extraction from the kidney by making a puncture and dilate a tract direct into the kidney through muscle wall and renal parenchyma
PROCEDURE	Extracorporeal Shock Wave Lithotripsy	Using Shock waves from outside the body targeted at a kidney stone causing the stone to fragment. The stones are broken into tiny pieces.

Timeline

• Start date: 2021-01-01
• Primary completion: 2022-08-22
• Completion: 2022-11-01
• First posted: 2021-10-13
• Last updated: 2022-02-22

Locations

1 site across 1 country: Egypt