NCT05073666

Prevalence and Risk Factors of Chronic Thrombo-embolic Disease After a Pulmonary Embolism Event

Prevalence and Risk Factors of Chronic Thrombo-embolic Disease After a Pulmonary Embolism Event The PACTE Registry

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 123 (actual)
• Sponsor: Centre Hospitalier Universitaire de Nice · Academic / Other
• Sex: All
• Age: 18 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

Venous thromboembolic disease (VTE) is a common clinical entity whose two manifestations are deep vein thrombosis (DVT) and pulmonary embolism (PE). After an acute PE, almost half of the patients complain residual dyspnea, despite well-conducted curative anticoagulation. Some will present persistent defects on lung scan-scintigraphy, without pulmonary hypertension. This condition defines Chronic-Thrombo-Embolic Disease(CTED). The prevalence of CTED after PE is poorly known as are its risk factors. The primary objective is to determine the prevalence of CTED at 3 or 6 months, depending on the provoked or unprovoked character, after a PE. The secondary objectives are: * To determine the potential risk factors for the occurrence of CTED. * To look for an association between the persistence of DVT and the occurrence of CTED. * To look for an association between the diagnosis of CTED and PE recurrence during the 12-month follow-up. * To determine the diagnostic performance of the clinician alone compared to the lung scintigraphy (gold standard) for the diagnosis of CTED. * To compare the impact on the quality of life (QoL) with or without CTED. * To determine the correlation between impaired QoL and the degree of residual obstruction on lung scintigraphy.

Conditions

• Chronic Emboilism

Interventions

Type	Name	Description
OTHER	NO INTERVENTION	NO INTERVENTION

Timeline

• Start date: 2021-01-01
• Primary completion: 2023-02-03
• Completion: 2023-02-03
• First posted: 2021-10-11
• Last updated: 2025-03-06

Locations

1 site across 1 country: France