NCT05069779

Diazepam and Blood Pressure Regulation

The Acute Effects of Diazepam on Blood Pressure Regulation

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: University of Brasilia · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to determine the acute effects of diazepam on beat-to-beat blood pressure variability and baroreflex control.

Detailed description

Benzodiazepines are widely prescribed for a variety of clinical conditions. However, its cardiovascular consequences remain controversial. In this study, the investigators sought to determine the acute effects of a single dose of oral diazepam (10mg) on resting beat-to-beat blood pressure variability and cardiac and sympathetic baroreflex sensitivity in a cohort of young, healthy individuals.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	Diazepam	Oral administration of 10 mg of diazepam

Timeline

• Start date: 2017-08-01
• Primary completion: 2019-05-20
• Completion: 2019-05-20
• First posted: 2021-10-06
• Last updated: 2021-10-06

Locations

1 site across 1 country: Brazil

Regulatory

• FDA-regulated drug study