Trials / Completed
CompletedNCT05065541
Positron Emission Tomography (PET) Imaging Study to Evaluate Enzyme Availability in the Central Nervous System Before and After CC-97489 Administration in Healthy Participants
A Phase 1, Open-label, Multi-part Positron Emission Tomography (PET) Imaging Study to Evaluate the Biodistribution and Radiation Dosimetry of the Monoacylglycerol Lipase (MGLL) PET Ligand [18F]T-401 and to Evaluate Fatty Acid Amide Hydrolase (FAAH) and MGLL Enzyme Availability in the Central Nervous System Using [11C]MK-3168 and [18F]T-401 PET Ligands Before and After Oral Administration of Single and Multiple Doses of CC-97489 in Healthy Adult Subjects
- Status
- Completed
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- 32 (actual)
- Sponsor
- Celgene · Industry
- Sex
- All
- Age
- 18 Years – 55 Years
- Healthy volunteers
- Accepted
Summary
The purpose of this study is to evaluate enzyme availability in the central nervous system before and after CC-97489 administration in healthy participants
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | CC-97489 | Specified dose on specified days |
| DRUG | [18F]T-401 | Specified dose on specified days |
| DRUG | [11C]MK-3168 | Specified dose on specified days |
Timeline
- Start date
- 2021-09-24
- Primary completion
- 2024-01-29
- Completion
- 2024-01-29
- First posted
- 2021-10-04
- Last updated
- 2024-02-16
Locations
1 site across 1 country: Belgium
Source: ClinicalTrials.gov record NCT05065541. Inclusion in this directory is not an endorsement.