NCT05062681

RCT on the Efficacy of Dexamethasone Versus Methyl Prednisolone in Covid-19 Infected Patients With High Oxygen Flow

Randomized Controlled Trial on the Efficacy of Dexamethasone Versus Methyl Prednisolone in Covid-19 Infected Patients With High Oxygen Flow

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims to evaluate the therapeutic activity and side effects of 16 mg/day dexamethasone in comparison to equivalent dose of MP (1mg/kg/day)for the management of COVID-19 infected patients.Moreover, and according to the importance of the IL-6/STAT-3 in triggering the inflammatory cascade and as the miRNAs are considered as prognostic markers, hence, the study aims also to study the impact of the used regimens on these biomarkers

Conditions

• COVID-19 Pandemic

Interventions

Type	Name	Description
DRUG	Dexamethasone	Patients will receive dexamethasone 8 mg q12hours
DRUG	Methylprednisolone	Patients will receive 1mg/kg/day in 2 divided doses over 30 minutes

Timeline

• Start date: 2021-09-15
• Primary completion: 2021-12-15
• Completion: 2022-03-15
• First posted: 2021-09-30
• Last updated: 2021-09-30

Locations

1 site across 1 country: Egypt