NCT05061875

Pharmacokinetics of Ceftriaxone Free Fraction

Pharmacokinetics of Ceftriaxone Free Fraction Administered at High for the Treatment of Serious Infections

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 20 (estimated)
• Sponsor: Fundación Pública Andaluza para la gestión de la Investigación en Sevilla · Academic / Other
• Sex: All
• Age: 55 Years
• Healthy volunteers: —

Summary

Prospective observational follow-up study for the study and modeling of the pharmacokinetics of the free fraction of ceftriaxone in patients treated with high doses of ceftriaxone (greater than or equal to 4 grams per day).

Detailed description

A prospective follow-up observational study to study and model the pharmacokinetics of the ceftriaxone free fraction in patients treated with high doses of ceftriaxone (greater than or equal to 4 grams per day). it is a pilot study that has between 10 and 20 patients. This study will not condition the treatment of patients at any time. The samples will be processed after their extraction. The concentration of the samples will be analyzed using a high-performance gilent infinity liquid chromatograph coupled to a mass spectrometer using positive or negative ionization using electrospray.

Conditions

• Ceftriaxone Poisoning

Timeline

• Start date: 2021-03-01
• Primary completion: 2022-02-01
• Completion: 2022-02-01
• First posted: 2021-09-30
• Last updated: 2021-11-17

Locations

1 site across 1 country: Spain