NCT05061784

Routine Transcervical Thymectomy in MEN-1 Patients

Revisiting the Evidence for Routine Transcervical Thymectomy for the Prevention of Thymic Carcinoid Tumours in MEN-1 Patients a Case Series

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 7 (actual)
• Sponsor: National University Health System, Singapore · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

A case series was built after review of available literature by searching four databases (PubMed, Embase, Medline and Cochrane Library) for observational studies or case reports on routine prophylactic TCT for MEN-1 and the development of thymic carcinoids.

Detailed description

Introduction and Importance Malignant thymic carcinoids are uncommon but important entities among patients with multiple endocrine neoplasia type 1 (MEN-1). Current treatment guidelines advise the performance of a routine transcervical thymectomy (TCT) during parathyroidectomy, to prevent its development, although data on the yield of this prophylactic TCT is scarce. We aimed to revisit available literature to investigate and summarize the efficacy of routine TCT during neck exploration for parathyroidectomy, for the prevention of thymic carcinoid tumours among MEN-1 patients. Methods A case series was built after review of available literature by searching four databases (PubMed, Embase, Medline and Cochrane Library) for observational studies or case reports on routine prophylactic TCT for MEN-1 and the development of thymic carcinoids.

Conditions

• Multiple Endocrine Neoplasia Type 1 (MEN-1)
• Thymic Carcinoid

Interventions

Type	Name	Description
PROCEDURE	Routine thymectomy, which has been performed	There is no intervention

Timeline

• Start date: 2021-07-14
• Primary completion: 2021-08-20
• Completion: 2021-08-20
• First posted: 2021-09-30
• Last updated: 2021-09-30

Locations

1 site across 1 country: Singapore