NCT05060289

A Prognostic Model for Drug-induced Liver Injury in China

A Prognostic Model for Drug-induced Liver Injury in China : A Multi-center, Prospective Cohort Study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 3,000 (estimated)
• Sponsor: Beijing Friendship Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

A prospective, multi-center, non-interventional cohort study is going to conduct to explore the clinical characteristics, culprit drug(s) or herb(s), outcomes and risk factors of Drug-induced liver injury (DILI) in China and screen novel serum markers. A prognostic model incorporating with the novel serum marker(s) for DILI would be established and validated to imporve the prognosis of patients in China .

Detailed description

Research Objectives: 1. To establish a standardized multi-center, prospective DILI cohort nationwide and obtain long-term prognostic data. 2. To establish and verify prognostic model(s) of DILI in China. 3. To explore novel serum biomarkers for the prognosis of DILI.

Conditions

• Drug-induced Liver Injury

Timeline

• Start date: 2022-05-25
• Primary completion: 2026-12-31
• Completion: 2028-12-31
• First posted: 2021-09-29
• Last updated: 2025-09-22

Locations

13 sites across 1 country: China