NCT05059782

Efficacy and Safety of Involving Field Radiotherapy in the Oligo-lesions(Metastasis/Recurrent/Refractory) of Ovarian Cancer

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: Xi'an Jiaotong University · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In this study, The researchers sought to explore the efficacy and safety of involving field radiotherapy in the oligo-metastatic/recurrent/refractory ovarian cancer patients among different groups which include drug therapy alone, radiotherapy alone, and drug therapy plus radiotherapy by inviting clinical multi-center participation.

Detailed description

The recurrent or refractory ovarian cancer tends to recur repeatedly at increasingly short intervals, making treatment more and more difficult.Patients often have limited physical capacity to undergo repeated systematic treatment. Currently, NCCN（ national comprehensive cancer network ）guidelines recommend palliative radiotherapy in patients with local recurrence of ovarian cancer. With the progress of IMRT（ intensity modulated radiation therapy ）, SBRT ( stereotactic body radiation therapy ) and other radiotherapy technologies, better local tumor control rate can also be achieved, while minimizing the damage to surrounding normal tissues. In this study, the patients will be divided into groups according to their wishes: group A (drug therapy alone), group B (radiotherapy alone), and group C (radiotherapy plus drug therapy).The researchers sought to explore the the efficacy and safety of involving field radiotherapy in the oligo-metastatic/recurrent/refractory ovarian cancer patients in different groups after treatment by inviting multiple centers to participate in the study.

Conditions

• Ovarian Cancer
• Neoplasm, Ovarian
• Ovarian Neoplasm
• Ovary Neoplasms
• Neoplasm, Ovary
• Neoplasms, Ovary
• Ovary Neoplasm
• Neoplasms, Ovarian
• Ovary Cancer
• Cancer, Ovarian Stromal
• Cancers, Ovary
• Ovary Cancers
• Cancer, Ovarian
• Cancers, Ovarian
• Ovarian Cancers
• Cancer of Ovary
• Cancer of the Ovary

Interventions

Type	Name	Description
DRUG	chemotherapy, targeted therapeutics, immunotherapy	Chemotherapy drugs ,targeted drugs or Immune checkpoint inhibitors are taken throughout the body or a combination of these drugs according to clinical needs is performed when necessary.
RADIATION	IFRT, IMRT or SBRT	IFRT（involving field radiotherapy） IMRT （ intensity modulated radiation therapy） SBRT （stereotactic body radiation therapy）

Timeline

• Start date: 2021-10-10
• Primary completion: 2023-02-28
• Completion: 2024-09-01
• First posted: 2021-09-28
• Last updated: 2021-09-28

Locations

1 site across 1 country: China