NCT05050838

Prone Positioning for Brain-injured Patients With Severe ARDS (ProBrain)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 11 (actual)
• Sponsor: Fondation Ophtalmologique Adolphe de Rothschild · Network
• Sex: —
• Age: 18 Years – 95 Years
• Healthy volunteers: Not accepted

Summary

Prone position (PP) is a key component to treat hypoxemia in patients with severe acute respiratory distress syndrome (ARDS). However, most studies evaluating PP effects in patients with ARDS exclude those with brain-injuries without providing any medical evidence. This prospectice observational study aimed to investigate if prone positioning leads to significant modification of cerebral perfusion in brain-injured patients with ARDS.

Conditions

• Cerebral Blood Flow

Interventions

Type	Name	Description
OTHER	Transcranial Doppler (TCD)	TCD ultrasonography is based on the principle of the Doppler effect. According to this principle, ultrasound waves emitted from the Doppler probe are transmitted through the skull and reflected by moving red blood cells within the intracerebral vessels. The difference in the frequency between the emitted and reflected waves, referred to as the "Doppler shift frequency," is directly proportional to the speed of the moving red blood cells (blood flow). Cerebral blood flow (in cm/s) of the middle cerebral artery will be measured with TCD in blood-injured ARDS patients before and one hour after prone positioning (normal ranges: 48 to 72 cm/s).

Timeline

• Start date: 2018-08-01
• Primary completion: 2020-06-30
• Completion: 2020-06-30
• First posted: 2021-09-21
• Last updated: 2021-09-21

Locations

1 site across 1 country: France