NCT05048381

miRNA in Sweat, a Novel Digital Biomarker for Detection of Active Tuberculosis (TB)

miRNA in Sweat, a Novel Digital Biomarker for Detection of Active Tuberculosis

• Status: Withdrawn
• Phase: —
• Study type: Observational
• Enrollment: 0 (actual)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The detection of miRNA (non-coding ribonucleic acid) in the blood in the context of active tuberculosis is an innovative approach to the detection of new disease-specific biomarkers. The primary goal of this analysis is to define, for the first time, an miRNA fingerprint for tuberculosis in sweat. Samples that were collected as part of the Sweatb Study (NCT03667742) project are examined for the occurrence of disease-specific, non-coding miRNAs to define new biomarkers in the sweat. These biomarkers can be detected non-invasively and will help in the detection of patients with active tuberculosis.

Conditions

• Active Tuberculosis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Next Generation Sequencing	Next Generation Sequencing of sweat and whole blood samples for non-coding miRNAs to define biomarkers that enable to differentiate between patients with active tuberculosis, a differential diagnostic disease and healthy individuals.

Timeline

• Start date: 2021-09-06
• Primary completion: 2022-10-31
• Completion: 2022-10-31
• First posted: 2021-09-17
• Last updated: 2023-11-01