NCT05047510

GPC3 Targeted Fluorescence Image Guided Surgery of Hepatocellular Carcinoma

An Evaluation Study of GPC3 Targeted Fluorescence Imaging to Guide the Surgery of Hepatocellular Carcinoma

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Chinese Academy of Sciences · Other Government
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

This study is to evaluate whether intraoperative fluorescence imaging targeting GPC3 can aid improve the surgical accuracy of hepatocellular carcinoma. The main purposes of this study include: ① To raise the detection rate of hepatocellular carcinoma intraoperatively using the novel NIR-II fluorescence molecular imaging and the GPC-3 targeted fluorophore. ② To validate the safety and effectiveness of the designed GPC-3 targeted fluorophore for clinical application.

Conditions

• Hepatocellular Carcinoma

Interventions

Type	Name	Description
DRUG	Anti-GPC3-IRDye800CW	Drug Injection: Anti-GPC3-IRDye800CW

Timeline

• Start date: 2021-09-10
• Primary completion: 2025-12-31
• Completion: 2026-12-31
• First posted: 2021-09-17
• Last updated: 2023-08-30

Locations

2 sites across 1 country: China