NCT05046743

Intestinal Dysmotility: Effect of Colonic Load

Intestinal Dysmotility in Patients With Functional Digestive Symptoms

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: Hospital Universitari Vall d'Hebron Research Institute · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

Abnormal motility patterns in the jejunum can be detected in patients with prominent colonic distension, and it is not clear whether these abnormalities reflect a primary jejunal dysfunction or are due to a reflex distortion. The aim of the study is to determine the effect of colonic filling on jejunal postprandial motility using high-resolution manometry. Healthy subjects will be studied following a controlled, parallel, randomized, single-blind experimental design. On the study day, nutrients will be continuously infused in the proximal jejunum (2 Kcal/min) during a 2-h period to induce a steady-state postprandial motor pattern. Jejunal motility will be concomitantly recorded using a water-perfused, high-resolution manometry catheter. After 1 hour of postprandial recording (basal period), a gas mixture will be infused during 7.5 minutes via a rectal tube (720 mL or sham infusion), and jejunal motility will be recorded for another hour.

Conditions

• Healthy Volunteers

Interventions

Type	Name	Description
OTHER	Colonic gas load	Colonic infusion of gas via an anal cannula
OTHER	Sham load	Sham infusion of gas via an anal cannula

Timeline

• Start date: 2021-02-01
• Primary completion: 2021-05-30
• Completion: 2021-05-30
• First posted: 2021-09-16
• Last updated: 2021-09-29

Locations

1 site across 1 country: Spain