NCT05044741

Risk Factors of Perforated HSCR in Neonates

The Risk Factors for Bowel Perforation in Neonates With Hirschsprung Disease

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 600 (actual)
• Sponsor: Tongji Hospital · Academic / Other
• Sex: All
• Age: 0 Days – 30 Days
• Healthy volunteers: Not accepted

Summary

Hirschsprung's disease (HSCR) is a common digestive malformation with radiographic evidence of distal bowel obstruction and clinical signs of abdominal distension, vomiting, constipation, and failure to pass meconium. Bowel perforation (perforated HSCR) is a very serious complication of HSCR, but if this occurs it is most often in the neonatal period. The current study collected information on all cases diagnosed with perforated HSCR from multi-centers in China over 10 years, the aim was to evaluate the clinical features of perforated HSCR, and investigate possible risk factors for perforated HSCR in neonates.

Conditions

• Hirschsprung Disease
• Bowel; Perforation, Fetus or Newborn

Interventions

Type	Name	Description
PROCEDURE	Emergency surgical enterostomy	Emergency surgical enterostomy

Timeline

• Start date: 2006-01-01
• Primary completion: 2010-12-31
• Completion: 2019-12-31
• First posted: 2021-09-16
• Last updated: 2021-09-16