NCT05042817

Effect of Intrathecal Morphine on Urinary Bladder Function and Recovery in Patients Having a Cesarean Delivery

Effect of Intrathecal Morphine on Urinary Bladder Function and Recovery in Patients Having a Cesarean Delivery - A Double-blind Randomized Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 56 (actual)
• Sponsor: University of Liege · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The enhanced recovery anesthesia concept has been widely adopted, including cesarean delivery. Modern obstetrical anesthesia aims to offer an experience to a patient undergoing a cesarean delivery similar to normal vaginal delivery in order to maximize postoperative comfort and facilitate bonding between the mother and her newborn. Therefore, early removal of the bladder catheter has been recommended. However, this is challenged by the administration of intrathecal morphine recommended to provide long-lasting postoperative analgesia after cesarean delivery.

Detailed description

This double-blind, randomized trial investigates the effects of intrathecal morphine on urinary dynamics in women undergoing CD under spinal anesthesia. The hypothesis is that the addition of intrathecal morphine (ITM) will delay micturition in women undergoing cesarean delivery. The primary outcome is the effect of ITM on urodynamics the difference in time to micturition. The secondary outcome is the need for bladder re-catheterization.

Conditions

• Analgesia

Interventions

Type	Name	Description
DRUG	100 mcg morphine	The effect of intrathecal morphine on vesical function and the need for bladder re-catheterization after a cesarean delivery
DRUG	0.9% NaCl	NaCl 0.9%
DRUG	50 mg prilocaine + 2.5 mcg sufentanil	50 mg prilocaine + 2.5 mcg sufentanil
PROCEDURE	bilateral transverse abdominal plane block	20 mL of ropicavaine 0.375% on each side

Timeline

• Start date: 2021-10-01
• Primary completion: 2022-03-31
• Completion: 2022-12-31
• First posted: 2021-09-13
• Last updated: 2023-03-20

Locations

1 site across 1 country: Belgium