NCT05040308

Uganda PrEP and Harm Reduction Evaluation

Implementation Science Research on PrEP Delivery and Costing Within Harm Reduction Services for People Who Use Drugs in Uganda

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 300 (estimated)
• Sponsor: University of Washington · Academic / Other
• Sex: All
• Age: 15 Years – 80 Years
• Healthy volunteers: Accepted

Summary

This is an evaluation of programs to integrate PrEP into existing services for PWUD. PrEP will be delivered according to Uganda national guidelines and data from national monitoring and evaluation forms will be leveraged to address key outcomes. Additionally, research components will be implemented to support greater understanding of PrEP use and experiences of participants engaged with the PrEP programs.

Detailed description

The first facility-based medication-assisted treatment (MAT) program (with methadone) in Kampala launched in 2020, providing opportunity to integrate pre-exposure prophylaxis(PrEP) as part of a comprehensive HIV prevention package. Additionally, a community-based needle and syringe exchange program (NSP) provides opportunity to integrate PrEP and meet priorities of PWID while building rapport between providers and end-users. With two different service models - integrating PrEP into facility-based MAT and community-based NSP - there is a great opportunity to optimize the integration of PrEP and other HIV prevention services for PWUD. By integrating PrEP into two existing programs (MAT and NSP), this study will determine uptake and persistence of PrEP use and leverage these programs to conduct costing research and budget impact analysis.

Conditions

• HIV-1-infection

Interventions

Type	Name	Description
OTHER	Integrating PrEP delivery	Integration of PrEP delivery services in NSP and MAT programs

Timeline

• Start date: 2022-02-11
• Primary completion: 2025-12-31
• Completion: 2025-12-31
• First posted: 2021-09-10
• Last updated: 2025-04-15

Locations

1 site across 1 country: Uganda