NCT05040152

Weight Loss Intervention for the Reduction of Cancer Risk and Health Disparities in Rural Ohio

Address Obesity to Reduce Cancer Risk and Health Disparities in Rural Ohio

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Ohio State University Comprehensive Cancer Center · Academic / Other
• Sex: All
• Age: 20 Years – 64 Years
• Healthy volunteers: Accepted

Summary

This study determines the feasibility of a telephone-based weight lost intervention in reducing cancer risk and health disparities in rural Ohio. Obesity is the leading preventable cause of cancer, and obesity-related inflammation is linked to elevated cancer risk, independent of obesity itself. Rural populations are a vulnerable population in need of increased access to tailored strategies and benefit from weight loss interventions. This study aims to see whether a telephone-based intervention may help obese people in rural area to reduce body weight, so as to prevent obesity-related cancer.

Detailed description

PRIMARY OBJECTIVES: I. To determine the feasibility and acceptability of a 15-week telephone-based weight loss intervention among overweight/obese rural residents. II. To estimate the preliminary efficacy of the lifestyle modifications on weight loss, body composition (fat mass, percent body fat), inflammatory biomarkers (IL-6, TNF-alpha, and C-recreative protein \[CRP\]), and other disease risk factors (lipid profiles). OUTLINE: Participants are randomized to 1 of 2 arms. ARM I: Participants receive weekly telephone-based weight loss intervention for 15 weeks, including dietary recommendations tailored to their current weight and weight loss target, home-based aerobic and resistance exercise, and weekly telephone counseling session over 30-45 minutes. ARM II: Participants receive education brochures describing the American Institute for Cancer Research physical activity and dietary guidelines.

Conditions

• Obesity-Related Malignant Neoplasm

Interventions

Type	Name	Description
BEHAVIORAL	Dietary Counseling and Surveillance	Receive dietary recommendations
OTHER	Exercise Intervention	Complete home exercises
OTHER	Informational Intervention	Receive education brochures
OTHER	Questionnaire Administration	Ancillary studies
BEHAVIORAL	Telephone-Based Intervention	Receive telephone-based weight loss intervention

Timeline

• Start date: 2021-11-06
• Primary completion: 2022-05-17
• Completion: 2022-05-17
• First posted: 2021-09-10
• Last updated: 2025-06-17
• Results posted: 2025-06-17

Locations

1 site across 1 country: United States