NCT05037396

Evaluation of Number of Patient Eyes That Remained on or Switched to Anti-VEGF Treatment After Initiation of Broluciumab

Treatment History, Demographic Characteristics, Clinical Characteristics, and Early Treatment Patterns of Patients Who Received Brolucizumab for Neovascular Age-related Macular Degeneration: IRIS Registry Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 9,457 (actual)
• Sponsor: Novartis Pharmaceuticals · Industry
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

This was a retrospective cohort study to assess the treatment history, demographic characteristics, clinical characteristics, and early treatment patterns of patients who received brolucizumab for neovascular age-related macular degeneration using IRIS Registry.

Detailed description

This was a retrospective cohort study of patients with wet AMD who received brolucizumab. Evidence was generated from the IRIS registry to describe patient treatment histories, demographic and clinical characteristics, and early treatment patterns. Setting and study population: IRIS Registry EHR data from 10/08/2018 to the 03/31/2020 from patients with wet AMD who initiated brolucizumab were analyzed. Identification period of the index date: The patients fulfilling the selection criteria identified during the period from 10/08/2019 to 03/31/2020. Index date: Defined as the date of the earliest brolucizumab injection. Study Period: The period from 10/08/2018 to 03/31/2020. Pre-index period: The period 12 months prior to the index date. Post-index period: The period 4 months after the index date (not a required selection criterion; only for the assessment of select endpoints in a subgroup of patients).

Conditions

• Age-related Macular Degeneration (AMD)

Interventions

Type	Name	Description
DRUG	Brolucizumab	Participants received brolucizumab injection during the index period

Timeline

• Start date: 2020-03-05
• Primary completion: 2020-08-01
• Completion: 2020-08-01
• First posted: 2021-09-08
• Last updated: 2021-10-12

Locations

1 site across 1 country: United States