NCT05034848

Peripheral Artery Disease (PAD) : Its Effects on Bone

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 2 (actual)
• Sponsor: Centre Hospitalier Régional d'Orléans · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Prevalence of PAD and osteoporosis (OP) both get higher with age. Clinical and epidemiologic evidence have showed an increased cardiovascular risk in OP and bone loss and fragility fractures in patient with cardiovascular disease. This study will examine the relationship between vascular disease in legs and sBMD and vBMD at trabecular and cortical sites and bone microarchitecture.

Detailed description

The primary goal of our study is to determinate if presence of PAD is associated with lower sBMD and vBMD values at the tibias, assuming that BMD should be more alterate in the predominant vascular impairement site. Our secondary objectives are to : * determine if severity of PAD quantified by ankle brachial index ABI is associated to a decrease of BMD values defined by T-Score at the left hip, spine and legs, but also with volumetric values, assessed by HRpQCT at the non dominant radius and at both tibias. * determine the prevalence of osteoporosis in our population * To evaluate the relationships between ; * lipids and bone parameters * vit D and parathormone with PAD severity * levels of physical activity and both vascular and bone impairments

Conditions

• Bone
• Peripheral Artery Disease

Interventions

Type	Name	Description
PROCEDURE	Assessment of BMD by DXA and HRpQCT	* DXA : BMD assessment at the left hip, rachis and both legs * HRpQCT : Volumic Bone mineral density, cortical and trabecular parameters, at the non dominant radius and legs * Biological samples

Timeline

• Start date: 2021-03-31
• Primary completion: 2021-05-19
• Completion: 2021-05-19
• First posted: 2021-09-05
• Last updated: 2022-12-29

Locations

1 site across 1 country: France