NCT05034380

Epigenetic Effects of a Single Bout of Exercise on Cardiovascular Risk Factors and the Metabolome

Epigenetic Effects of a Single Bout of Exercise on Cardiovascular Risk Factors and the Metabolome in Lean and Overweight or Obese Subjects

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: East Carolina University · Academic / Other
• Sex: Male
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine the ability of acute exercise to regulate fat metabolism in muscle of overweight and obese people compared to lean people.

Detailed description

After being informed about the study details and possible risks and benefits, 15 overweight/obese and 15 lean participants gave written informed consent and were then screened and enrolled in the study. All participants then gave a muscle sample and ate a calorically controlled breakfast. Participants completed \~1 hour of cycling exercise on a stationary bike and gave a second muscle sample 4 hours after eating breakfast.

Conditions

• Obesity
• Type 2 Diabetes
• Cardiovascular Diseases
• Acute Exercise

Interventions

Type	Name	Description
BEHAVIORAL	Acute exercise	All participants consumed a standardized, high carbohydrate meal (7 kcal/kg; 60% carbohydrate, 25% fat, 15% protein) and completed an exercise testing trial, expending a total of 650 kcal upon completion 4h later.

Timeline

• Start date: 2014-09-14
• Primary completion: 2015-10-06
• Completion: 2016-03-14
• First posted: 2021-09-05
• Last updated: 2021-09-05

Locations

1 site across 1 country: United States