NCT05034367

Reference Ranges for the Cough Responsiveness to Inhaled Mannitol

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 132 (actual)
• Sponsor: Kuopio University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Accepted

Summary

Cough is the most common reason why people seek medical attention in developed countries. The main mechanisms for prolonged cough are hypersensitivity of the cough reflex arc, sputum production, and constriction of the airway smooth muscles. Recognition of the mechanism in each cough patient is essential for the efficient management of prolonged cough. At present, there are no feasible tests for everyday clinical work to recognize cough reflex arc hypersensitivity. Mannitol test was originally developed for asthma diagnostics. We have recently shown that it can also be used to investigate hypersensitive cough reflex arc. The purpose of the present study is to create reference ranges for normal cough responsiveness to inhaled mannitol. Without them, the test cannot be utilized in everyday clinical work. For that purpose we will perform mannitol test in 140 subjects, who are at least 18 years old and without any chronic respiratory symptoms or disorders. The subjects will be recruited in three centers: University of Eastern Finland and: John Hunter Hospital in Australia.The material will be collected 1.9.2021-31.12.2023. We apply funding for both personnel and material expences, to carry out this study.

Conditions

• Cough

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Mannitol challenge	Inhalation challenge with dry powder of mannitol with a maximal cumulative dose of 635 mg

Timeline

• Start date: 2022-01-17
• Primary completion: 2023-12-31
• Completion: 2023-12-31
• First posted: 2021-09-05
• Last updated: 2024-09-19

Locations

2 sites across 2 countries: Australia, Finland